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Name        Fentanyl

Accession Number.   DB00813  (APRD00347, DB05853, DB06055, DB06220, DB05564)

Type.       Small Molecule

Groups Approved, Illicit, Investigational,

Vet            approved

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Fentanyl for sale, a potent opioid agonist, develop in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly use to treat chronic cancer pain or in anesthesia. Also, is related to other opioids like morphine and oxycodone.

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Fentanyl’s high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.

This medication is to help relieve severe ongoing pain (such as due to cancer). Fentanyl belongs to a class of drugs known as opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain. Do not use the patch form of fentanyl to relieve pain that is mild or that will go away in a few days. This medication is not for occasional (“as needed”) use.

FDA approved in 1968.

Structure

Fentanyl Structure

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Fentanyl intravenous or intramuscular injections indicates for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also use with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, The intravenous or intramuscular injections uses oxygen for anesthesia in high risk patients.

Sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.

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